Harold Russell - Best Supporting Actor and Honorary Award (1947)
Harold Russell was a real life war hero who, following a tragic accident in the field, lost both of his hands. Having them replaced with hooks, he was taken off active duty and ended up making training films for the army.
Revered director William Wyler spotted him and decided to re-write a part in his anti-war drama 'The Best Years of Our Lives' for him. Back then, non-professional actors wouldn't get a look in, but Russell managed to come completely out of the blue and scoop the Best Supporting Actor Oscar.
In addition he secured an honorary award for, "bringing hope and courage to his fellow veterans through his appearance". This also guarantees him one of the least prolific careers of any Oscar winner, with only four films in his half a decade career.